PCI complexes: pretty complex interactions in diverse signaling pathways

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• 作者：Kim ; Tae-Houn ; Hofmann ; Kay ; von Arnim ; Albrecht G. ; Chamovitz ; Daniel A.
• 关键词：COP9 ; signalosome ; proteasome ; eIF3 ; translational control ; protein degradation ; Arabidopsis ; protein complex ; photomorphogenesis ; SCF complex ; Plant Science ; Cell biology
• 刊名：Trends in Plant Science
• 出版年：2001
• 出版时间：August 1, 2001
• 年：2001
• 卷：6
• 期：8
• 页码：379-386
• 全文大小：80.1 K

文摘

Three protein complexes (the proteasome regulatory lid, the COP9 signalosome and eukaryotic translation initiation factor 3) contain protein subunits with a well defined protein domain, the PCI domain. At least two (the COP9 signalosome and the lid) appear to share a common evolutionary origin. Recent advances in our understanding of the structure and function of the three complexes point to intriguing and unanticipated connections between the cellular functions performed by these three protein assemblies, especially between translation initiation and proteolytic protein degradation.