Escitalopram in the treatment of major depressive disorder: An open-label naturalistic trial in various settings

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• 作者：L. Hranov* ; I. Staleva
• 关键词：Desymmetrization ; Hydrolysis ; Half-ester ; Monoalkyl malonate derivatives
• 刊名：Journal of Affective Disorders
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：107
• 期：Supplement 1
• 页码：S92-S93
• 全文大小：63 K

文摘

The highly efficient selective monohydrolysis of symmetric diesters has been applied to monohydrolysis of several dialkyl malonates and their derivatives. The best conditions apply 0.8–1.2 equiv of aqueous KOH with a co-solvent, THF or acetonitrile, at 0 °C. The procedure is highly practical, yielding the corresponding half-esters in high yields in a straightforward manner, without inducing decarboxylation. It was found that the selectivity tends to become higher with increased hydrophobicity.