The Lyssavirus glycoprotein: A key to cross-immunity
详细信息 查看全文
- 作者：Sindisiwe G. Buthelezia ; b ; Heini W. Dirrb ; Ereck Chakauyaa ; Rachel Chikwambaa ; Lennart Martensc ; d ; Tsepo L. Tsekoaa ; Stoyan H. Stoycheva ; Sstoychev@csir.co.za" class="auth_mail" title="E-mail the corresponding author ; Elien Vandermarlierec ; d ; e
- 关键词：RABV ; Rabies virus ; G protein ; glycoprotein ; PEP ; Post-exposure prophylaxis ; RIG ; Anti-rabies immunoglobulin ; HRIG ; Human anti-rabies immunoglobulins ; ERIG ; Equine anti-rabies immunoglobulins ; mAbs ; Monoclonal antibodies ; WHO ; World Health Organization ; VSV ; Vesicular stomatitis virus ; ASA ; Accessible surface area ; RSA ; Relative solvent accessibility
- 刊名：Virology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：498
- 期：Complete
- 页码：250-256
- 全文大小：2333 K
文摘
- •
The current PEP has raised safety and availability concerns.
- •
Cocktails of mAbs have been proposed as alternative treatment.
- •
Amino acid conservation amongst Lyssavirus G proteins was studied.
- •
Possible cross-neutralizing B-cell epitopes were proposed.