Casein Kinase 1 Coordinates Cohesin Cleavage, Gametogenesis, and Exit from M Phase in Meiosis II

详细信息    查看全文

• 作者：Orlando Argü ; ello-Miranda¹ ; ² ; ³ ; Ievgeniia Zagoriy¹ ; ³ ; Valentina Mengoli¹ ; Julie Rojas¹ ; Katarzyna Jonak¹ ; Tugce Oz¹ ; Peter Graf¹ ; Wolfgang Zachariae¹ ; ⁴ ; ^{zachar@biochem.mpg.de}
• 关键词：meiosis II ; protection of centromeric cohesin ; Rec8 cleavage by separase ; exit from meiosis ; spindle disassembly ; gametogenesis ; sporulation ; casein kinase 1 ; shugoshin ; PP2A
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：37-52
• 全文大小：5880 K
• 卷排序：40

文摘

The conserved kinase Hrr25 enables separase to cleave centromeric cohesin in meiosis II Hrr25 phosphorylates the Rec8 subunit of cohesin and removes its protector Sgo1-PP2A Hrr25 initiates spore development by inducing the synthesis of prospore membranes Hrr25 mediates exit from meiosis II by inducing the destruction of M-phase kinases