Inhibition of 11β-hydroxysteroid dehydrogenase type 1 ameliorates obesity-related insulin resistance
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- 作者：Shiying Shao ; Xiaojie Zhang ; Muxun Zhang ; eucalyptus1981@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Obesity ; Insulin resistance ; Glucocorticoid ; 11β-hydroxysteroid dehydrogenase type 1
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：474-480
- 全文大小：667 K
文摘
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Excess 11β-HSD1is implicated in obesity related insulin resistance.
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Increased 11β-HSD1 is correlated with WHR, BMI, and HOMA-IR.
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11β-HSD1 inhibition improves insulin resistance.
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The mechanism relies on insulin-signaling pathway and adipocytokine production.