Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen

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• 作者：Fabricia Petronilho^a ; ^{fabricia.petronilho@unisul.br" class="auth_mail" title="E-mail the corresponding author} ; Monique Michels^a ; Luciné ; ia G. Danielski^a ; Mariana Pereira Goldim^a ; Drielly Florentino^a ; Andriele Vieira^a ; Mariana G. Mendonç ; a^a ; Moema Tournier^a ; Bá ; rbara Piacentini^a ; Amanda Della Giustina^a ; Daniela D. Leffa^b ; Gregó ; rio W. Pereira^c ; Volnei D. Pereira^d ; Joã ; o Batista Teixeira Da Rocha^e
• 关键词：Diphenyl diselenide ; DSS induced-colitis ; Ebselen ; Oxidative stress ; Ulcerative colitis
• 刊名：Pathology - Research and Practice
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：212
• 期：9
• 页码：755-760
• 全文大小：1145 K

文摘

The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)₂ and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats.

Methods

The effects of (PhSe)₂ and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations.

Results

Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)₂ improved this response. Moreover, the treatment with (PhSe)₂ decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model.

Conclusions

The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)₂ more effective than EB.