Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese
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- 作者：Chuan-Chia Changa ; b ; Hsin-An Changa ; Wen-Hui Fangc ; Tieh-Ching Changa ; San-Yuan Huanga ; b ; hsy@ndmctsgh.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Serotonin transporter ; Neuroticism ; Tri-allelic 5-HTTLPR polymorphism ; Gender differences ; Anxiety ; Depression
- 刊名：Journal of Affective Disorders
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：207
- 期：Complete
- 页码：422-428
- 全文大小：494 K
文摘
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The SS genotype of the bi-allelic 5-HTTLPR was associated with neuroticism in men.
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When combining the rs25531 (tri-allelic approach), the association became stronger.
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Men with the tri-allelic S′S′ genotype also had higher anxiety/depression scores.
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Women showed a non-significant pattern across both the 5-HTTLPR classifications.
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Our data provide further support for rs25531 strengthening the effects of 5-HTTLPR.