Prolyl hydroxylase 3 overexpression accelerates the progression of atherosclerosis in ApoE∿∿mice
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- 作者：Hui Liu ; Yanfei Xia ; Beibei Li ; Jinyu Pan ; Mei Lv ; Xuyang Wang ; Fengshuang An ; anfengshuang1028@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; Prolyl hydroxylase 3 ; MAPK ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 April 2016
- 年：2016
- 卷：473
- 期：1
- 页码：99-106
- 全文大小：3729 K
文摘
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Our study demonstrated that PHD3 is involved in the progression of atherosclerosis in ApoE−/− mice for the first time.
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PHD3 is associated with the expression of inflammatory cytokines such as ICAM-1, VCAM-1, MCP-1, IL-1β and TNF-αin vivo and in vitro.
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We found that PHD3 could activate the MAPK signaling pathway in HUVECs with ox-LDL treatment.