Our study demonstrated that PHD3 is involved in the progression of atherosclerosis in ApoE−/− mice for the first time.
PHD3 is associated with the expression of inflammatory cytokines such as ICAM-1, VCAM-1, MCP-1, IL-1β and TNF-αin vivo and in vitro.
We found that PHD3 could activate the MAPK signaling pathway in HUVECs with ox-LDL treatment.