MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background
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- 作者：Zhimin Yea ; Jun Fanga ; 1 ; Shujun Daib ; Yuezhen Wanga ; Zhenfu Fua ; Wei Fenga ; Qichun Weic ; Pintong Huangd ; huangpintong@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：EC ; esophageal carcinoma ; SA-β-Gal ; senescence-associated β-galactosidase ; SIRT1 ; Sirtuin1 ; ADR ; adrmycin ; PCR ; polymerase chain reaction ; PNUTS ; phosphatase-1 nuclear targeting subunit ; DMSO ; dimethylsulfoxide
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：370
- 期：2
- 页码：216-221
- 全文大小：1493 K
文摘
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Expression level of miR-34a induced by DNA damage agent adriamycin was p53- and time-dependent in ESCC.
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MiR-34a significantly inhibited cell growth via down-regulation of Sirtuin1 and up-regulation of P53/P21.
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High concentrations of miR-34a may inhibit cell growth in KYSE-410 and KYSE-450 cell lines with mutant-type p53 gene.