The biological effectiveness of intermittent irradiation as a function of overall treatment time: development of correction factors for linac-based stereotactic radiotherapy
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- 作者：Benedict ; Stanley H. ; Lin ; Peck-Sun ; Zwicker ; Robert D. ; Huang ; David T. ; Schmidt-Ullrich ; Rupert K. A.
- 关键词：Stereotactic radiosurgery ; Stereotactic radiotherapy ; U-87 MG
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：1997
- 出版时间：March 1, 1997
- 年：1997
- 卷：37
- 期：4
- 页码：765-769
- 全文大小：457 K
文摘
Purpose: Continuous irradiation of relatively short duration as administered in gamma-ray stereotactic radiosurgery (SRS) is biologically not equivalent to the more protracted intermittent exposures during accelerator-based radiosurgery with multiple arcs. Accelerator-based SRS and fractionated stereotactic radiotherapy (SRT) is currently performed with a high degree of variability in equipment and techniques resulting in highly variable treatment delivery times. The present work is designed to quantify the effects of radiation delivery times on biological effectiveness. For this, the intermittent radiation delivery schemes, typical for linac-based SRS/SRT, have been simulated in vitro to derive biological correction factors.