The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer
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- 作者：Yanling Wanga ; 1 ; Yumin Zhua ; 1 ; Qiong Wanga ; 1 ; Huijun Hua ; 1 ; Zhongwu Lia ; b ; Dongmiao Wangb ; Wei Zhangc ; Bin Qic ; Jinhai Yeb ; Heming Wub ; Hongbing Jiangb ; Laikui Liua ; c ; Jianrong Yanga ; b ; Jie Chenga ; omfs_njmu@163.com" class="auth_mail" title="E-mail the corresponding author ; leonardo_cheng@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：LSD1 ; Histone demethylase ; Epigenetic modification ; Oral cancer
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 April 2016
- 年：2016
- 卷：374
- 期：1
- 页码：12-21
- 全文大小：3608 K
文摘
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Aberrant LSD1 overexpression in OSCC was significantly associated with tumor aggressiveness and shorter overall survival.
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Increased abundance of LSD1 was detected along with disease progression in DMBA- or 4NQO-induced OSCC animal models.
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Genetic or pharmacological depletion of LSD1 in OSCC cells resulted in potent anti-cancer effects both in vitro and in vivo.
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Intraperitoneal delivery of LSD1 chemical inhibitors resulted in impaired OSCC xenograft overgrowth.