Chondroitin sulfate-capped super-paramagnetic iron oxide nanoparticles as potential carriers of doxorubicin hydrochloride
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- 作者：Neha Mallicka ; nehamallick.sch@jamiahamdard.ac.in" class="auth_mail" title="E-mail the corresponding author ; nehamallick@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohammed Anwara ; md.anwar2008@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohammed Asferb ; mdasfer@iitk.ac.in" class="auth_mail" title="E-mail the corresponding author ; Syed Hassan Mehdid ; saeedimam@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohammed Moshahid Alam Rizvid ; mrizvi@jmi.ac.in" class="auth_mail" title="E-mail the corresponding author ; Amulya Kumar Pandac ; amulya@nii.res.in" class="auth_mail" title="E-mail the corresponding author ; Sushama Talegaonkara ; stalegaonkar@jamiahamdard.ac.in" class="auth_mail" title="E-mail the corresponding author ; Farhan Jalees Ahmada ; fjahmad@jamiahamdard.ac.in" class="auth_mail" title="E-mail the corresponding author ; farhanja_2000@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chondroitin sulfate A (PubChem CID ; 53477710) ; Doxorubicin hydrochloride (PubChem CID ; 443939)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：546-556
- 全文大小：3663 K
文摘
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A facile, one-pot green synthesis method was used.
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Chondroitin sulfate (CS) was an efficient capping agent for synthesis of SPIONs.
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CS interacted with iron oxide via bidentate chelation.
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DOX was entrapped onto the nanocarriers by electrostatic interaction with CS.
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IC50 value was decreased for DOX-loaded SPIONs than plain DOX.