Synthesis of strontium substituted hydroxyapatite whiskers used as bioactive and mechanical reinforcement material

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• 作者：Yuhui Shen^a ; ¹ ; Jinhao Liu^a ; ¹ ; Kaili Lin^b ; ^{lklecnu@yahoo.com.cn} ; Weibin Zhang^a ; ^{weibin@medmail.com.cn}
• 关键词：Hydroxyapatite ; Strontium substitution ; Fiber technology ; Bioceramics ; Cytocompatibility ; Mechanical reinforcement
• 刊名：Materials Letters
• 出版年：2012
• 出版时间：1 March 2012
• 年：2012
• 卷：70
• 期：Complete
• 页码：76-79
• 全文大小：489 K

文摘

The strontium substituted hydroxyapatite (SrHA) whiskers with 6.6 mol % of Ca replaced by Sr were successfully synthesized via homogeneous precipitation method. The product had a width of 0.2-8 ¦Ìm and length up to 155 ¦Ìm. The human osteoblast-like cell (MG-63) culture showed that Sr substitution could stimulate the proliferation of MG-63 at certain extracted concentrations. Furthermore, the addition of SrHA whiskers could significantly improve the mechanical properties of calcium phosphate cement (CPC). The 5 wt. % SrHA whisker reinforced CPC revealed the highest compressive strength of 2.92 MPa, which was almost 2-times higher than that of the pure CPC. Our study indicated that SrHA whisker might be a potential candidate as a new bioactive and mechanical reinforcement material for hard tissue regeneration applications.