Increased levels of brain serotonin correlated with MMP-9 activity and IL-4 levels resulted in severe experimental autoimmune encephalomyelitis (EAE) in obese mice
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- 作者：M. Hasana ; c ; J.-E. Seoa ; c ; K.A. Rahamana ; c ; M.-J. Kangb ; c ; B.-H. Jungb ; c ; O.-S. Kwona ; c ; oskwon@kist.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HIAA ; 5-hydroxyindole acetic acid ; 5-HT ; 5-hydroxytryptamine ; serotonin ; AMCS ; average mean clinical score ; AUC ; area under the curve ; DA ; dopamine ; DHBA ; 3 ; 4-dihydroxybenzylamine ; DOPAC ; 3 ; 4-dihydroxyphenyl acetic acid ; EAE ; experimental autoimmune encephalomyelitis ; HFD ; high-fat diet ; HVA ; homovanillic acid ; LPS ; lipopolysaccharide ; MCSs ; mean clinical scores ; MMPs ; matrix metalloproteinases ; MOG ; myelin oligodendrocyte glycoprotein ; MS ; multiple sclerosis ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：319
- 期：Complete
- 页码：168-182
- 全文大小：2633 K
文摘
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Increased clinical scores were observed in HFD-EAE mice than ND-EAE mice.
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HFD-EAE mice showed significantly higher MMP-9, NADPH oxidase activities and lower IL-4 levels than ND-EAE mice.
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Increased brain 5-HT, DA, and their reduced metabolism were found in HFD-EAE than ND-EAE or control mice.
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5-HT levels were significantly correlated with MMP-9 activity and IL-4 levels resulted in the severity of EAE in HFD mice.