The influence of n-3 fatty acids on maternal behavior and brain monoamines in the perinatal period

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• 作者：Akiko Harauma^a ; Takayuki Sagisaka^b ; Taku Horii^b ; Yoshitake Watanabe^b ; Toru Moriguchi^a ; ^b ; ^{moriguchi@azabu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：n-3 Def ; n-3 fatty acid deficiency ; n-3 Adq ; n-3 fatty acid adequacy ; ARA ; arachidonic acid ; 20 ; 4n-6 ; DHA ; docosahexaenoic acid ; 22 ; 6n-3 ; GD ; gestational day ; PD ; postpartum day ; 5-HT ; serotonin ; 5-hydroxytryptamine ; 5-HIAA ; 5-hydroxyindole acetic acid ; NE ; norepinephrine ; MHPG ; 3-methoxy-4hydroxyphenylglycol ; DA ; dopamine ; DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; 3-MT ; 3-methoxy-4hydroxyphehylethylamine ; HVA ; homovanillic acid
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：107
• 期：Complete
• 页码：1-7
• 全文大小：603 K

文摘

The aim of this study was to use n-3 fatty acid-deficient pregnant mice to assess maternal behavior in the perinatal period. Female mice were fed either an n-3 fatty acid-deficient (n-3 Def) or -adequate (n-3 Adq) diet for two generations. The nest score and volume of the n-3 Def dams were lower than those of the n-3 Adq dams. In the observation of the post-delivery conditions, 40% of the n-3 Def dams attacked their newborns or did not nurse them. The brain docosahexaenoic acid (DHA) levels of the n-3 Def dams were lower than those of the n-3 Adq dams. In the hippocampus, moreover, positive correlations were observed between the DHA and the 5-HT or 5-HIAA, and a negative correlation was observed between the DHA and the DA. These results suggest that dietary n-3 fatty acids may normalize the development of maternal behavior and prevent postpartum depression.