Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase
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- 作者：Satoshi Endoa ; sendo@gifu-pu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Namiki Miyagia ; Toshiyuki Matsunagaa ; Akira Harab ; Akira Ikaria
- 关键词：DHRS11 ; 17β-Hydroxysteroid dehydrogenase ; 3β-Hydroxysteroid dehydrogenase ; Dehydroepiandrosterone ; Neurosteroid ; Isolithocholic acid
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 March 2016
- 年：2016
- 卷：472
- 期：1
- 页码：231-236
- 全文大小：691 K
文摘
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Human DHRS11 is for the first time characterized enzymatically.
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It is found to be a reductive 3β/17β-hydroxysteroid dehydrogenase.
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Its properties differ from those of known 17β-hydroxysteroid dehydrogenases.
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Its potential roles in sex hormone, neurosteroid, androgen, estrogen and bile acid metabolism are is proposed.
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Its mRNA is highly expressed in testis, kidney, intestine, brain and cancer cells.