Prospective observational study to compare oral topical metronidazole versus 0.2% chlorhexidine gluconate to prevent nosocomial pneumonia
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- 作者：Ying Chen ; MD ; PhDa ; 1 ; En-Qiang Mao ; MD ; PhDa ; 1 ; Yi-Jun Yang ; RNa ; Shu-Yuan Zhao ; RNa ; Cheng Zhu ; MDa ; Xiao-Fei Wang ; MD ; PhDb ; Feng Jing ; RNa ; Hui-Qiu Sheng ; MDa ; Zhi-Tao Yang ; MD ; PhDa ; c ; yangzhitao@hotmail.fr" class="auth_mail" title="E-mail the corresponding author ; Er-Zhen Chen ; MD ; PhDa
- 关键词：Oral hygiene ; Chlorhexidine gluconate ; Intensive care units ; Nosocomial pneumonia ; Ventilator-associated pneumonia
- 刊名：American Journal of Infection Control
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：44
- 期：10
- 页码：1116-1122
- 全文大小：479 K
文摘
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We investigated the long-term effectiveness of oral hygiene with chlorhexidine gluconate in prevention of nosocomial pneumonia in a medical-surgical intensive care unit.
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Chlorhexidine gluconate (0.2%) may reduce the incidence of nosocomial pneumonia and ventilator-associated pneumonia in an intensive care unit, but not in microbiologic epidemiology when noted.
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Oral hygiene with 0.2% chlorhexidine gluconate showed a benefit in the prevention of nosocomial pneumonia, including ventilator-associated pneumonia in intensive care units, considering the safety and less selective pressure of antibiotic resistance.