Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition
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- 作者：Lauren E. Salminena ; LSalminen@mail.umsl.edu" class="auth_mail" title="E-mail the corresponding author ; Peter R. Schofieldb ; c ; Kerrie D. Pierceb ; Yi Zhaod ; Xi Luod ; Youdan Wangd ; David H. Laidlawe ; Ryan P. Cabeene ; Thomas E. Conturof ; David F. Tateg ; Erbil Akbudakf ; Elizabeth M. Laneh ; Jodi M. Heapsg ; Jacob D. Bolzeniusa ; Laurie M. Bakera ; Lee M. Caglea ; Robert H. Paula ; g
- 关键词：AGT ; M235T ; M268T ; rs699 ; White matter ; Cognition
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：296
- 期：Complete
- 页码：85-93
- 全文大小：640 K
文摘
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The AGT M268T SNP is associated with cardiovascular abnormalities.
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The 268T variant is a risk factor for reduced white matter in healthy adults.
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The superior longitudinal fasciculus and cingulum are vulnerable to 268T.
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Attention/processing speed and language are compromised among TT genotypes.
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White matter and cognition are impacted independent of hyperintensity burden.