Effect of dietary n-3 fatty acids supplementation on fatty acid metabolism in atorvastatin-administered SHR.Cg-Lepr^cp/NDmcr rats, a metabolic syndrome model

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• 作者：Abdullah Al Mamun^a ; Michio Hashimoto^a ; ^{michio1@med.shimane-u.ac.jp} ; Masanori Katakura^a ; Yoko Tanabe^a ; Satoru Tsuchikura^b ; Shahdat Hossain^a ; ^c ; Osamu Shido^a
• 关键词：Metabolic syndrome ; N-3 PUFA ; Atorvastatin ; Hypercholesterolemia and hyperlipidemia
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：372-379
• 全文大小：931 K
• 卷排序：85

文摘

Long-term administration of atorvastatin inhibits n-3PUFAs synthesis in the liver. Long-term administration of atorvastatin inhibits Δ5-desaturase, Δ6-desaturases and elongase-5 mRNA expression in liver. Dietary n-3PUFAs supplementation restore the decreased n-PUFAs level in liver.