Progesterone receptor in the prostate: A potential suppressor for benign prostatic hyperplasia and prostate cancer

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• 作者：RuiQi Chen^a ; ^{richen@prostatecentre.com} ; Yue Yu^a ; Xuesen Dong^a ; ^b
• 关键词：AR ; androgen receptor ; ARPI ; androgen receptor pathway inhibition ; CRPC ; castrate-resistant prostate cancer ; PCa ; prostate cancer ; BPH ; benign prostate hyperplasia ; ERα ; estrogen receptor-α ; PR ; progesterone receptor ; PRA ; PR isoform A ; PRB ; PRB isoform B ; PRC ; PR isoform C ; CAF ; cancer-associated fibroblast
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：91-96
• 全文大小：556 K
• 卷排序：166

文摘

Progesterone receptor (PR) localizes in the prostate stroma. PR suppresses stromal cell proliferation with implications in BPH. PR suppresses tumor-favoring microenvironment in the prostate. PR regulates stromal differentiation and potentially prevents reactive stroma. The impact of PR on prostate diseases warrants further investigations.