Compound C (Cc) was injected to estradiol- or oil-implanted ovariectomized rat hindbrain.
Cc inhibits hindbrain adenosine 5′-monophosphate-activated protein kinase (AMPK).
Estradiol regulates hindbrain Cc effects on hypothalamic AMPK.
Estradiol determines hypothalamic targets of Cc-altered norepinephrine signaling.
Cc completely or partially represses feeding in presence versus absence of estradiol.