Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice
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- 作者：Tae Joon Won ; Bongjoon Kim ; Yunjung Lee ; Joon Seok Bang ; Eun Seul Oh ; Jong-Sun Yoo ; Kyeong Eun Hyung ; Joowon Yoon ; Sehee Hwang ; Eon Sub Park ; So-Young Park ; Kwang Woo Hwang
- 关键词：Atopic dermatitis ; Kimchi ; Lactobacillus plantarum CJLP133 ; NC/Nga mouse ; House-dust mite ; Type 1 helper T cells ; Regulatory T cells ; Axillary lymph node
- 刊名：Cellular Immunology
- 出版年：2012
- 出版时间：May-June, 2012
- 年：2012
- 卷：277
- 期：1-2
- 页码：49-57
- 全文大小：1248 K
文摘
Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-¦Ã in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-¦Ã, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-¦Ã and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-¦Ã. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.