Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones

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• 作者：Chung-Kyu Ryu ; ^{ckryu@ewha.ac.kr} ; Joo Hee Yoon ; Ae Li Song ; Hyun Ah Im ; Ji Young Kim ; Aram Kim
• 关键词：Pyrido[1 ; 2-a]indole-1 ; 4-dione ; Benzo[f]pyrido[1 ; 2-a]indole-6 ; 11-dione ; Antimicrobial compounds ; Antifungal ; Fungi ; Substitution effects
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：1 January, 2012
• 年：2012
• 卷：22
• 期：1
• 页码：497-499
• 全文大小：307 K

文摘

Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents.