Icaritin protects against oxidative stress-induced injury in cardiac H9c2 cells via Akt/Nrf2/HO-1 and calcium signalling pathways
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- 作者：Si Wan Leia ; 1 ; Guozhen Cuia ; b ; 1 ; George Pak Heng Leungc ; gphleung@hku.hk" class="auth_mail" title="E-mail the corresponding author ; Sharon Chui Wah Luka ; Maggie Pui Man Hoia ; Liang Wanga ; Gail B. Mahadyd ; Simon Ming Yuen Leea ; simonlee@umac.mo" class="auth_mail" title="E-mail the corresponding author
- 关键词：Icaritin ; Cardiac H9c2 cells ; Oxidative stress ; NF-E2-related factor 2 ; Calcium ion
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：18
- 期：part_PA
- 页码：213-223
- 全文大小：2102 K
文摘
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A natural product named icaritin exhibits novel in vitro cardioprotective effect.
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Cardioprotective action of icaritin is involved in Nrf2 and calcium signalling pathways.
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Icaritin represents a promising candidate in the prevention of oxidative stress induced cardiac damage.