Outcomes Among Older Patients Receiving Implantable Cardioverter-Defibrillators for Secondary Prevention: From the NCDR ICD Registry

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• 作者：Jarrod K. Betz ; MD^a ; David F. Katz ; MD^b ; ^c ; Pamela N. Peterson ; MD ; MSPH^b ; ^c ; ^d ; Ryan T. Borne ; MD^b ; ^c ; Sana M. Al-Khatib ; MD ; MHS^e ; Yongfei Wang ; MS^f ; ^g ; Carolina Malta Hansen ; MD^e ; David D. McManus ; MD ; ScM^h ; Jehu S. Mathew ; MD^b ; ^c ; Frederick A. Masoudi ; MD ; MSPH^b ; ^c ; ^{fred.masoudi@ucdenver.edu}
• 关键词：arrhythmia ; elderly ; electrophysiology
• 刊名：Journal of the American College of Cardiology
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：69
• 期：3
• 页码：265-274
• 全文大小：818 K
• 卷排序：69

文摘

Clinical trials of implantable cardioverter-defibrillators (ICDs) for secondary prevention of sudden cardiac death were conducted nearly 2 decades ago and enrolled few older patients.ObjectivesThis study assessed morbidity and mortality of older patients receiving ICDs for secondary prevention in contemporary clinical practice.MethodsWe identified 12,420 Medicare beneficiaries from the National Cardiovascular Data Registry ICD Registry undergoing first-time secondary prevention ICD implantation between 2006 and 2009 in 956 U.S. hospitals. Risks of death, hospitalization, and admission to a skilled nursing facility (SNF) were assessed over 2 years in age strata (65 to 69, 70 to 74, 75 to 79, and ≥80 years of age) using Medicare claims. The adjusted association between age and outcomes was evaluated using multivariable models.ResultsThe mean age was 75 years at the time of implantation; 25.3% were <70 years of age and 25.7% were ≥80 years of age. Overall, the risk of death at 2 years was 21.8%, ranging from 14.7% among those <70 years of age to 28.9% among those ≥80 years of age (adjusted risk ratio [aRR]: 2.01; 95% confidence interval [CI]: 1.85 to 2.33; p for trend <0.001). The cumulative incidence of hospitalizations was 65.4%, ranging from 60.5% in those <70 years of age to 71.5% in those ≥80 years of age (aRR: 1.27; 95% CI: 1.19 to 1.36; p for trend <0.001). The cumulative incidence of admission to a SNF ranged from 13.1% among those <70 years of age to 31.9% among those ≥80 years of age (aRR: 2.67; 95% CI: 2.37 to 3.01; p for trend <0.001); SNF admission risk was highest in the first 30 days.ConclusionsAlmost 4 in 5 older patients receiving a secondary prevention ICD survives at least 2 years. High hospitalization and SNF admission rates, particularly among the oldest patients, identify substantial care needs after device implantation.