Lincomycin hydrochloride loaded albumin microspheres for controlled drug release, produced by Supercritical Assisted Atomization
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- 作者：Renata Adamia ; radami@unisa.it" class="auth_mail" title="E-mail the corresponding author ; Sara Liparotia ; Giovanna Della Portaa ; Pasquale Del Gaudiob ; Ernesto Reverchona
- 关键词：Supercritical Assisted Atomization ; Lincomycin hydrochloride ; BSA ; Nanostructured microparticles ; Controlled release
- 刊名：The Journal of Supercritical Fluids
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：119
- 期：Complete
- 页码：203-210
- 全文大小：2977 K
文摘
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Microparticles of BSA loaded with lincomycin hydrochloride are produced by SAA.
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In one process BSA denaturation and drug entrapment in microparticles are obtained.
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Spherical particles with a mean diameter in the range 1–2 μm are produced.
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High drug loading efficiency are obtained.
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The dissolution rate of the drug is reduced, its release is prolonged over 6 days.