A method for measuring disease-specific iduronic acid from the non-reducing end of glycosaminoglycan in mucopolysaccharidosis type II mice
详细信息 查看全文
- 作者：Yohta Shimadaa ; shimada_y@jikei.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Taichi Wakabayashia ; b ; Kazumasa Akiyamaa ; c ; Hiroo Hoshinaa ; b ; Takashi Higuchia ; Hiroshi Kobayashia ; b ; Yoshikatsu Etod ; Hiroyuki Idaa ; b ; Toya Ohashia ; b
- 关键词：Mucopolysaccharidosis type II ; MPS II ; Glycosaminoglycan ; Iduronic acid ; HPLC
- 刊名：Molecular Genetics and Metabolism
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：117
- 期：2
- 页码：140-143
- 全文大小：404 K
文摘
2-Sulfoiduronic acid from the non-reducing end of GAGs is a biomarker of MPS II.
We developed a pathological iduronic acid (PIA) assay.
The PIA assay could clearly distinguish MPS II mice from wild-type mice.