Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH
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- 作者：Vasiliki I. Hatzi ; vh@ipta.demokritos.gr" class="auth_mail" title="E-mail the corresponding author ; Maria Karakosta ; Katarzyna Barszczewska ; Ioanna Karachristou ; Gabriel Pantelias ; Georgia I. Terzoudi
- 关键词：Caffeine ; Asymmetric cell division ; Chromatid breaks ; Aneuploidy ; Micronuclei
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：793
- 期：Complete
- 页码：71-78
- 全文大小：1150 K
文摘
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Caffeine (≥1 mM) indirectly induces in vitro chromatid breaks and micronuclei in PBL.
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Mitosis entrance with incomplete DNA replication may underlie the action of caffeine.
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Caffeine concentrations (≥10 μΜ) in vitro induce asymmetric cell division in PBL.
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The CBMN assay combined with iFISH is valuable for asymmetric cell division testing.