Elevated Semaphorin 5A correlated with Th1 polarization in patients with chronic immune thrombocytopenia
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- 作者：Mingen Lyu ; Yang Li ; Yating Hao ; Tiantian Sun ; Wenjie Liu ; Cuicui Lyu ; Rongfeng Fu ; Huiyuan Li ; Feng Xue ; Xiaofan Liu ; Lei Zhang ; Renchi Yang ; rcyang65@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immune thrombocytopenia ; Semaphorin 5A ; Th1 ; Cytokines ; Treatment
- 刊名：Thrombosis Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：136
- 期：5
- 页码：859-864
- 全文大小：602 K
文摘
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Higher level of Plasma Sema5A was observed in chronic ITP patients.
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Plasma Sema5A was positively correlated with the plasma IFN-γ, IFN-γ/IL-4 ratio.
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Plasma Sema5A was inversely correlated with receptor plexin-B3 expression.
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Decreased plasma Sema5A and elevated plexin-B3 mRNA were found after treatment.