Higher level of Plasma Sema5A was observed in chronic ITP patients.
Plasma Sema5A was positively correlated with the plasma IFN-γ, IFN-γ/IL-4 ratio.
Plasma Sema5A was inversely correlated with receptor plexin-B3 expression.
Decreased plasma Sema5A and elevated plexin-B3 mRNA were found after treatment.