Novel immunostimulators with a thiazolidin-4-one ring promote the immunostimulatory effect of human iNKT cells on the stimulation of Th2-like immune responsiveness via GATA3 activation in vitro
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- 作者：Ming Menga ; Chunxiao Lia ; Fei Yanga ; Hua Chenb ; Xiaoliu Lib ; Yongbin Yanga ; Dongzhi Chena ; chenddzz@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Invariant natural killer T cells ; Immunostimulators ; α-Galcer ; IFN-γ/IL-4
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：353-358
- 全文大小：919 K
文摘
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CH2b could further promote the activated iNKTs proliferation.
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CH2b could markedly enhance cytotoxic ability of the activated iNKTs.
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CH2b could increase production of Th2-like cytokines by activated iNKTs.
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CH2b could induce Th0 differentiation into Th2 subset via GATA 3 signaling pathway.
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CH2b might be used for correction of balance disorders of Th1/Th2.