This study provides an example of a health promotion campaign addressed at primary school students, with the aim of improving children's knowledge, correcting habits in the context of food safety, and enhancing the children's understanding of microorganisms and their functions. Children attending a program based on (1) mostly theoretical knowledge or (2) mostly practical information (with the scientific method of ¡°learn by playing¡±) were evaluated before and after the intervention using drawings and semi structured interviews to test the intervention effectiveness. Data extracted from an analysis of 492 drawings and of 141 interviews showed that practical classes are more effective than theory classes. Data also show that children's drawings could be used to simplify and consolidate the deep learning of scientific topics, and also to evaluate the successfulness of health promotion campaigns targeting young children. This should contribute to the amelioration of children's awareness of hygiene and food contamination-related risks, leading to significant benefits for primary prevention of foodborne illness.