Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestry
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- 作者：Pedro M. Azevedoa ; pedroming@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Tony R. Merrimanb ; Ruth K. Toplessb ; Nigel J. Wilsonc ; Sue Crengled ; Diana R. Lennone
- 关键词：Rheumatic fever ; Rheumatic heart disease ; Interleukin-6 (IL-6) ; Interleukin-1 receptor antagonist (IL-1RA) ; cytotoxic T-lymphocyte associated protein 4 (CTLA4)
- 刊名：Cytokine
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：201-206
- 全文大小：328 K
文摘
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RF incidence is among the world’s highest amid NZ individuals of Polynesian ancestry.
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We found IL-6 promoter rs1800797 might influence susceptibility for RHD in this population.
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IL1RN rs447713 may influence the severity of carditis in this population.
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These finding may help guiding future clinical trials.