miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5

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• 作者：Edit Miko^a ; Zoltá ; n Margitai^b ; Zsolt Czimmerer^a ; Ildik&#xf3 ; Vá ; rkonyi^c ; Balá ; zs Dezső ; ^c ; Á ; rpá ; d Lá ; nyi^d ; Zsolt Bacs&#xf3 ; ^b ; Beá ; ta Scholtz^a ; ^{scholtz@dote.hu}
• 关键词：Small cell lung cancer ; miR-126 ; SLC7A5 ; G1 delay
• 刊名：FEBS Letters
• 出版年：2011
• 出版时间：20 April 2011
• 年：2011
• 卷：585
• 期：8
• 页码：1191-1196
• 全文大小：690 K

文摘

Despite intensive efforts to improve therapies, small cell lung cancer (SCLC) still has a dismal median survival of 18 months. Since miR-126 is under-expressed in the majority of SCLC tumors, we investigated the effect of miR-126 overexpression on the proliferation and cell cycle distribution of H69 cells. Our results demonstrate that miR-126 inhibits proliferation of H69 cells, by delaying the cells in the G1 phase. Short interfering RNA (siRNA) mediated suppression of SLC7A5, a predicted target of mir-126, has the same effect on H69 cells. We also show for the first time that SLC7A5 is a direct target of miR-126.