Improved controlled release of protein from expanded-pore mesoporous silica nanoparticles modified with co-functionalized poly(n-isopropylacrylamide) and poly(ethylene glycol) (PNIPAM-PEG)

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• 作者：Erick Yu^a ; ^b ; Allison Lo^b ; Linda Jiang^b ; Bradley Petkus^b ; Nazar Ileri Ercan^b ; ¹ ; Pieter Stroeve^b ; ^{pstroeve@ucdavis.edu}
• 关键词：Poly(n-isopropylacrylamide) ; Poly(ethylene glycol) ; Protein delivery ; Mesoporous silica nanoparticles
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：297-300
• 全文大小：1202 K
• 卷排序：149

文摘

MSNs with 11 nm pores and gated with PNIPAM were synthesized. Further surface functionalization with PEG in the pores improved BHb release. The inclusion of PEG minimized BHb deformation.