SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis
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- 作者：Maksim V. Baranov1 ; Natalia H. Revelo1 ; Ilse Dingjan1 ; Riccardo Maraspini2 ; Martin ter Beest1 ; Alf Honigmann2 ; Geert van den Bogaart1 ; 3 ; geert.vandenbogaart@radboudUMC.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：phagocytosis ; dendritic cell ; actin ; cytoskeleton ; phosphoinositides ; phosphatidylionositol 3 ; 4-bisphosphate ; SWAP70 ; rho-GTPases ; Rac1 ; STED microscopy
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1518-1531
- 全文大小：5658 K
文摘
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SWAP70 is transiently recruited to the nascent cup of emerging phagosomes
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Phagosomal recruitment of SWAP70 is driven by RAC1 and phosphoinositides
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SWAP70 tethers concentric rings of F-actin on the phagosomal membrane
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Absence of SWAP70 results in phagocytic defects