Amino acid-peptide-catalyzed enantioselective Morita–Baylis–Hillman reactions

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• 作者：Melissa M. Vasbinder ; Jason E. Imbriglio and Scott J. Miller
• 刊名：Tetrahedron
• 出版年：2006
• 出版时间：4 December 2006
• 年：2006
• 卷：62
• 期：49
• 页码：11450-11459
• 全文大小：916 K

文摘

Peptide-based catalysts in the presence of proline as co-catalyst have been found to catalyze the enantioselective ketone-based Morita–Baylis–Hillman reaction. The co-catalyst combination has afforded catalysis where enantioselectivities of up to 81 % have been obtained.