GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole–tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a
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- 作者：Jason E. Imbriglio ; Sookhee Chang ; Rui Liang ; Subharekha Raghavan ; Darby Schmidt ; Abby Smenton ; Scott Tria ; Thomas O. Schrader ; Jae-Kyu Jung ; Craig Esser ; Andrew K.P. Taggart ; Kang Cheng ; Ester Carbal
- 关键词：Niacin ; GPR109a ; Atherosclerosis
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：15 April 2009
- 年：2009
- 卷：19
- 期：8
- 页码：2121-2124
- 全文大小：282 K
文摘
5-Alkyl and aryl-pyrazole–tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.