Immobilization of gold nanoparticles on solid supports utilizing DNA hybridization

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• 作者：Peschel ; S. ; Ceyhan ; B. ; Niemeyer ; C.M. ; Gao ; S. ; Chi ; L. ; Simon ; U.
• 关键词：Gold nanoparticles ; Nucleic acids ; Surface nanostructures ; Self-assembly
• 刊名：Materials Science and Engineering: C
• 出版年：2002
• 出版时间：January 2, 2002
• 年：2002
• 卷：19
• 期：1-2
• 页码：47-50
• 全文大小：196 K

文摘

Self-organization of colloidal metal nanoparticles into micro- and nanostructured assemblies is currently of tremendous interest promising to find new size- and structure-dependent physical properties. Owing to its unique recognition capabilities and physicochemical stability, DNA can be used as a molecular linker for gold nanoparticles and is a promising construction material for their precise spatial positioning. Due to the enormous specificity of nucleic acid hybridization, the site-specific immobilization of DNA-functionalized gold colloids (1–40 nm) to solid supports, previously functionalized with a complementary DNA array, allows the fabrication of novel nanostructured surface architectures. Scanning force microscopy (SFM), used to characterize the intermediate steps of the DNA-directed immobilization (DDI) on a gold substrate, provides initial insight into the specificity and efficiency of this technique.