Nutrient sensing, signal transduction and immune responses

详细信息    查看全文

• 作者：Jessica Walls^a ; Linda Sinclair^c ; David Finlay^a ; ^b ; ^{finlayd@tcd.ie}
• 关键词：Immunometabolism ; Nutrient sensing ; Glucose ; Glutamine ; Amino acids ; SCFA ; LCFA ; Cholesterol ; Oxysterols ; Srebp ; mTORC1 ; c-Myc ; GCN2 ; Slc7a5 ; CD36 ; LXR ; Glycolysis ; OxPhos ; Lymphocyte ; Macrophage
• 刊名：Seminars in Immunology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：28
• 期：5
• 页码：396-407
• 全文大小：3002 K
• 卷排序：28

文摘

Nutrients are important cues that shape immune responses. Glucose and glutamine impact upon AMPK activation and O-GlcNAcylation with important implications for T cell responses. MTORC1 and GCN2 are important amino acid sensitive signalling pathways with widespread immunoregulatory roles. Short and long chain fatty acids exert anti-inflammatory actions through multiple signalling pathways. Cholesterol and Oxysterols control metabolism and immune function through the Srebp transcription factors.