Longitudinal study of cognitive and cerebral metabolic changes in Parkinson's disease

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• 作者：Toru Baba^a ; ^{t-baba@med.tohoku.ac.jp} ; Yoshiyuki Hosokai^a ; Yoshiyuki Nishio^a ; Akio Kikuchi^b ; Kazumi Hirayama^c ; Kyoko Suzuki^d ; Takafumi Hasegawa^b ; Masashi Aoki^b ; Atsushi Takeda^e ; Etsuro Mori^a
• 关键词：PD ; Parkinson's disease ; PD-MCI ; PD with mild cognitive impairment ; PDD ; PD dementia ; PD-CogNL ; cognitively normal PD ; MMSE ; Mini-Mental State Examination ; FDG-PET ; 18F-fluorodeoxyglucose positron emission tomography ; ADAS ; Alzheimer's Disease Assessment Scale ; ANOVAs ; analyses of variance ; DLPFC ; dorsolateral prefrontal cortex
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：372
• 期：Complete
• 页码：288-293
• 全文大小：1114 K
• 卷排序：372

文摘

Longitudinal changes in cerebral glucose metabolism in 46 patients with Parkinson’s disease (PD) were retrospectively analyzed. 18F-fluorodeoxyglucose positron emission tomography was undertaken both at baseline and after 3 years of follow-up. Three of 29 cognitively normal PD patients and 3 of 17 PD patients with mild cognitive impairment (PD-MCI) developed dementia during follow-up. Dementia converters showed parieto-occipital hypometabolism at baseline regardless of their initial cognitive status. A finding of parieto-occipital hypometabolism is useful in predicting dementia in PD.