Spinal dorsal horn astrocytes: New players in chronic itch

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• 作者：Makoto Tsuda^a ; ^b ; ^{tsuda@phar.kyushu-u.ac.jp}
• 关键词：Astrocytes ; Spinal dorsal horn ; STAT3 ; Lipocalin-2 ; Mouse
• 刊名：Allergology International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：1
• 页码：31-35
• 全文大小：1216 K
• 卷排序：66

文摘

Chronic itch is a debilitating symptom of inflammatory skin conditions, such as atopic dermatitis, and systemic diseases, for which existing treatment is largely ineffective. Recent studies have revealed the selective neuronal pathways that are involved in itch sensations; however, the mechanisms by which itch turns into a pathological chronic state are poorly understood. Recent advances in our understanding of the mechanisms producing chronic itch have been made by defining causal roles for astrocytes in the spinal dorsal horn in mouse models of chronic itch including atopic dermatitis. Understanding the key roles of astrocytes may provide us with exciting insights into the mechanisms for itch chronicity and lead to a previously unrecognized target for treating chronic itch.