In vitro exposure system for study of aerosolized influenza virus

详细信息    查看全文

• 作者：Hannah M. Creager^a ; ^b ; Hui Zeng^a ; Joanna A. Pulit-Penaloza^a ; Taronna R. Maines^a ; Terrence M. Tumpey^a ; Jessica A. Belser^a ; ^jax6@cdc.gov
• 关键词：Influenza ; Aerosols ; Cell culture ; Viral replication ; Avian viruses
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：62-70
• 全文大小：1127 K
• 卷排序：500

文摘

Human respiratory epithelial cells were exposed to aerosolized influenza virus. Fewer than ten PFU were required to infect the Calu-3 human cell line. Infection route influenced susceptibility of primary alveolar cells to infection. Aerosolized virus was able to penetrate an apical mucin layer.