Focal adhesion kinase (FAK) regulates polymerase activity of multiple influenza A virus subtypes
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- 作者：Husni Elbahesha ; b ; helbahes@uthsc.edu" class="auth_mail" title="E-mail the corresponding author ; Silke Bergmanna ; Charles J. Russella ; b
- 关键词：Influenza A virus ; Focal adhesion kinase ; Replication ; Polymerase activity ; Nucleoprotein ; Minigenome ; Kinase-dead ; Proximity ligation assay
- 刊名：Virology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：499
- 期：Complete
- 页码：369-374
- 全文大小：741 K
文摘
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Inhibition of FAK kinase activity significantly reduced IAV polymerase activity.
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FAK kinase activity promotes efficient H1N1, H5N1 and H7N9 polymerase activity.
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FAK-NP interactions were observed during virus infection and minigenome assay.