Synthesis of α-santonin derivatives for diminutive effect on T and B-cell proliferation and their structure activity relationships

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• 作者：Praveen K. Chinthakindi^a ; ^b ; Jasvinder Singh^c ; ^d ; Shilpa Gupta^c ; Amit Nargotra^e ; Priya Mahajan^e ; Anupurna Kaul^c ; Zabeer Ahmed^c ; Surrinder Koul^a ; ^{skoul@iiim.ac.in} ; Payare L. Sangwan^a ; ^{plsangwan@iiim.ac.in}
• 关键词：α-Santonin ; Immunosuppressant ; ConA ; LPS ; T and B cell ; SARs ; In silico study
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：1047-1058
• 全文大小：1170 K
• 卷排序：127

文摘

Synthesis of 20 α-santonin derivatives. Several derivatives were identified potent immunosuppressant molecules. One of the molecules showed 45% TNF-α inhibition at 10 μM concentration. The active molecules target TNF-α protein rather than IMPDH.