The contribution of different adipose tissue depots to plasma plasminogen activator inhibitor-1 (PAI-1) levels

详细信息    查看全文

• 作者：Sunelle A. Barnard¹ ; ^{13024787@nwu.ac.za" class="auth_mail" title="E-mail the corresponding author} ; Marlien Pieters ; ¹ ; ^{marlien.pieters@nwu.ac.za" class="auth_mail" title="E-mail the corresponding author} ; Zelda De Lange ^{zelda.delange@nwu.ac.za" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BMI ; body mass index ; CT ; computed tomography ; IL-1 ; interleukin-1 ; IL-6 ; interleukin-6 ; NRF ; National Research Foundation ; MetS ; metabolic syndrome ; mRNA ; messenger ribonucleic acid ; PAI-1 ; plasminogen activator inhibitor-1 ; PAI-1act ; PAI-1 activity ; PAI-1ag ; PAI-1 antigen ; PCR ; polymerase chain reaction ; SCAT ; subcutaneous adipose tissue ; TGF-β1 ; transforming growth factor B ; TNF-α ; tumour necrosis factor-α ; VAT ; visceral adipose tissue ; VLDL ; very low density lipoproteins ; WC ; waist circumfer
• 刊名：Blood Reviews
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：30
• 期：6
• 页码：421-429
• 全文大小：421 K

文摘

Increased plasma plasminogen activator inhibitor-1 (PAI-1) level is considered a mechanistic pathway through which obesity contributes to increased cardiovascular disease risk. Abdominal adipose tissue specifically, is a major PAI-1 source with visceral adipose tissue (VAT), an ectopic fat depot, generally considered to produce more PAI-1 than subcutaneous adipose tissue. However, this does not necessarily lead to increased plasma PAI-1 levels. This review provides an overview of studies investigating the association between body fat distribution and plasma PAI-1 levels. It discusses factors that influence this relationship and also considers the contribution of other tissue to plasma PAI-1 levels, placing the relative contribution of adipose tissue into perspective. In conclusion, the relationship between VAT and plasma PAI-1 levels is not fixed but can be modulated by a number of factors such as the size of the subcutaneous adipose tissue depot, ethnicity, possibly genetics and other obesity-related metabolic abnormalities.