Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease
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- 作者：J.-S. Zhanga ; &dagger ; ; S.-F. Zhoua ; &dagger ; ; Q. Wanga ; J.-N. Guoa ; H.-M. Lianga ; J.-B. Denga ; b ; dengjinbohn@163.com" class="auth_mail" title="E-mail the corresponding author ; W.-Y. Hea ; hewy001@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-amyloid protein ; BACE1 ; β-site APP-cleaving enzyme 1 ; CAT ; catalase ; eIF2α ; Eukaryotic initiation factor-2α ; Gas ; gastrodin ; H2O2 ; hydrogen peroxide ; MDA ; malondialdehyde ; NF-κB ; nuclear factor-κB ; PKR/eIF2 ; αprotein kinase/Eukaryotic initiation factor-2α ; PRI ; PKR inhibitor ; SD ; standard deviation ; SOD ; superoxide dismutase
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：325
- 期：Complete
- 页码：1-9
- 全文大小：1373 K
文摘
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Gastrodin improves learning and memory abilities of Tg2576 mice.
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Gastrodin attenuates intracellular oxidative stress in hippocampi of Tg2576 mice.
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Gastrodin suppresses BACE1 expression and PKR/eIF2α pathway in hippocampi of Tg2576 mice.
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Gastrodin suppresses BACE1 via inhibiting PKR/eIF2α in SH-SY5Y cells under oxidative stress.