Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine
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- 作者：Anees Rahmana ; anees@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author ; Faisal Thayyullathila ; t.faisal@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author ; Siraj Pallichankandya ; sirajpk@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author ; Sehamuddin Galadaria ; b ; sehamuddin@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author
- 关键词：4EBP1 ; eukaryotic translation initiation factor 4E-binding protein 1 ; aCDase ; acid ceramidase ; Akt ; Akt/protein kinase B ; aSMase ; acid sphingomyelinase ; CalA ; calyculin A ; CAPP ; ceramide activated protein phosphatase ; CDase ; ceramidase ; Cer ; ceramide ; Desip ; desipramine ; DMSO ; dimethyl sulfoxide ; FB1 ; Fumonisin B1 ; FBS ; fetal bovine serum ; GCS ; glucosylceramide synthase ; GSH ; glutathione ; GSK3β ; glycogen synthase kinase 3 beta ; H2O2 ; hydrogen peroxide ; OH&minus ; hydroxyl radical ; IAP ; inhibitor
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：273-289
- 全文大小：12135 K
文摘
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Sanguinarine induces caspase-dependent apoptosis in human leukemic cells.
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Sanguinarine induces H2O2-dependent ceramide generation leading to apoptosis.
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Ceramide mediates Akt dephosphorylation via protein phosphatase 1.
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Antileukemic action of sanguinarine is mediated via H2O2-Cer-Akt signaling axis.