Sertraline-Associated Cholestasis and Ductopenia Consistent with Vanishing Bile Duct Syndrome

详细信息    查看全文

• 作者：Má ; ire A. Conrad ; MD ; MS¹ ; ^{conradm@email.chop.edu" class="auth_mail" title="E-mail the corresponding author} ; Jiawei Cui² ; Henry C. Lin ; MD¹
• 关键词：DILI ; Drug-induced liver injury ; SSRI ; Selective serotonin reuptake inhibitor ; VBDS ; Vanishing bile duct syndrome
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：169
• 期：Complete
• 页码：313-315.e1
• 全文大小：595 K

文摘

An adolescent with depression treated with sertraline developed cholestasis and bile duct paucity, which resolved with medication discontinuation. Vanishing bile duct syndrome is an acquired destruction of interlobular bile ducts. This type of drug-induced liver injury has been associated with other medications and requires practitioners' awareness of potential hepatotoxicity.