Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells
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- 作者：Jina Leea ; b ; 1 ; Min Seong Kima ; b ; 1 ; Min Aeh Kima ; b ; Yeun Kyu Janga ; b ; ykjang@yonsei.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CMZ ; calmidazolium chloride ; CaM ; calmodulin ; CSCs ; cancer stem cells ; DMSO ; dimethyl sulfoxide ; ECCs ; embryonal carcinoma cells ; ESCs ; embryonic stem cells ; FACS ; fluorescent-activated cell sorting ; ICM ; inner cell mass ; LIF ; leukemia inhibitory factor ; Oct4 ; octamer-binding transcription factor 4 ; PI ; propidium iodide ; qRT-qPCR ; quantitative real-time PCR ; RIPA ; radioimmunoprecipitation assay ; SDS ; sodium dodecyl sulfonate ; Sox2 ; Sex determining region Y-box 2
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：86-92
- 全文大小：837 K
文摘
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CMZ was known to induce apoptosis in some cancer cells but not in CSCs yet.
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CMZ inhibits growth of ECCs, a surrogate model of CSCs.
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The growth inhibition of ECCs by CMZ is related with apoptotic cell death.
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The CMZ-induced growth inhibition of ECCs is partly due to down regulation of c-Myc.
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Our data shed light on the potential therapeutic impact of CMZ on CSCs.