Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health
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- 作者：Sachiko Itoha ; Atsuko Arakia ; Takahiko Mitsuib ; Chihiro Miyashitaa ; Houman Goudarzia ; Seiko Sasakic ; Kazutoshi Chod ; Hiroyuki Nakazawae ; Yusuke Iwasakie ; Nobuo Shinoharaf ; Katsuya Nonomuraf ; g ; Reiko Kishia ; rkishi@med.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：PFASs ; perfluoroalkyl substances ; PFOS ; perfluorooctane sulfonate ; PFOA ; perfluorooctanoate ; E2 ; estradiol ; T ; testosterone ; P4 ; progesterone ; LH ; luteinizing hormone ; FSH ; follicle-stimulating hormone ; SHBG ; steroid hormone binding globulin ; PRL ; prolactin ; INSL3 ; insulin-like factor 3
- 刊名：Environment International
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：51-59
- 全文大小：501 K
文摘
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We explored the effects of maternal PFASs on reproductive hormones in cord blood.
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PFOS associated with increased E2, and decreased T/E2, P4, and inhibin B in males.
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PFOA levels were positively associated with inhibin B levels in males.
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Inverse associations of PFOS with P4 and PRL were found in female infants.
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The threshold of PFOS and PFOA effects on fetal reproductive hormones was indicated.